eCHO Systems

Dr. Paula Meleady

Research interest

We are applying proteomic and phosphoproteomic analysis (including site-specific phosphorylation) to characterize recombinant Chinese hamster ovary (CHO) cell in bioprocess-relevant conditions. These proteomic datasets can then be integrated with other ‘omic datasets, such as miRNA, mRNA, metabolome, etc. with a view to identifying engineering targets to improve the efficiency of biopharmaceutical production from CHO cells.

eCHO Project
Prashant is pursuing his PhD as part of the eCHO Systems ITN under my supervision and is using proteomic approaches (including phosphoproteomic analyses) to characterize recombinant CHO cells lines. The protein data from these studies will be integrated with other ‘omic data generated as part of the ITN Network.

About the Lab
My lab has a particular interest in in the application of proteomics and mass spectrometry technologies to understanding biological systems. We are using proteomic approaches to characterize recombinant Chinese hamster ovary cell to identify protein engineering targets to improve the efficiency of biopharmaceutical production. My lab also has research interests in clinical proteomics (uveal melanoma and pancreatic cancer) for biomarker discovery and identification of cell surface proteins that may be amenable to therapeutic intervention.