eCHO Systems

Heena Dhiman, BOKU

What kind of tips would you give to future PhDs taking part in an ITN?

The training program is extremely well planned for inculcating the skills within the ESRs to attain their objectives successfully. It’s a good opportunity to learn from the highly proficient scientists involved in understanding of CHO systems at various levels across Europe in different academic and industrial centers.


Course works have also been designed keeping into consideration the experimental or informatics background of the recruited researchers so that they are exposed to both the fields and end up as a versatile researcher.


Why have you chosen to do a PhD in an international collaboration project?

To get familiarized with different working environments and learn as much as possible from all the academic as well as industrial collaborators.


My lab and the PhD-project I am doing
Aim: To highlight the association of short and long term epigenetic modifications with the phenotypic drift of CHO cell lines and thereby provide recommendations for improvised cell line development.

Objective: To create a genome-wide epigenetic regulatory network for the CHO cell lines and use the derived compendium of information to further deduce the genomic locations which are accessible to transcription factors and least susceptible to silencing. Such regions that are most stably and reliably expressed can be targeted to engineer the cells for improved production of therapeutic proteins.